Prof. Nathaniel COMFORT
Johns Hopkins University, Baltimore, USA
Hypes and Hopes of Precision Medicine: a historical perspective
Nathaniel Comfort is a professor in the Department of the History of Medicine at The Johns Hopkins University with interests in the histories of genetics, eugenics, genomics, and personalized medicine. He has two degrees in biology and one—the PhD—in history. He is the author of The Tangled Field: Barbara McClintock’s Search for the Patterns of Genetic Control (Harvard, 2001) and The Science of Human Perfection: How Genes Became the Heart of American Medicine (Yale, 2012), and editor of and contributor to The Panda’s Black Box: Opening Up the Intelligent Design Controversy. In 2015-2016 he was the Blumberg Professor of Astrobiology at the Library of Congress/NASA. In addition to his scholarly work, he writes for The Atlantic, The Nation, the New York Times Book Review, National Public Radio, Nature, Science, The Believer, The Point, and elsewhere. He blogs at Genotopia and tweets from @nccomfort. His current research involves the history of DNA.
Dr. Catherine BOURGAIN
INSERM, Cermes3, Paris, FRANCE
Societal and Ethical Challenges of Precision Medicine
Catherine Bourgain is a researcher in human genetics and statistics at the Institut National de la Santé et de la Recherche Médicale (INSERM) since 2002, and a member of the Inserm ethics committee. In September 2012, she joined Cermes3 (Centre de Recherche Médecine, Sciences, Santé, Santé mentale, Société). Her research focuses on the repositioning of scientific, medical, ethical and economic issues induced by broadband genomics technologies in the context of the development of personalized medicine. She is particularly interested in the evolution of the links between research and clinical practices. In addition, she is the vice-president of the Fondation Sciences Citoyennes, which aims to bring science and innovation into the field of democratic debate, and which is particularly interested in synthetic biology.
Prof. Joseph NADEAU
Pacific Northwest Research Institute, Seattle, USA
The continuum from mendelian to complex diseases
Dr. Nadeau is internationally-recognized for his work on mouse models of human disease. He has been a pioneer in comparative genomics, genetics and systems studies of mouse models of human disease, with an emphasis on transgenerational epigenetic effects on metabolism and cancer, and most recently on phenotypic ‘noise’ in metabolic systems. His work is contributing to a revolution in the ways that we understand inheritance of phenotypic variation and disease susceptibility. He is currently Principal Scientist at the Pacific Northwest Research Institute (Seattle). He is the former chair and James H, Jewell Professor of Genetics at Case Western Reserve University School of Medicine. He is the founding director of the Mouse Genome Informatics Project and the Mouse Genome Database, founding director of the Ohio GI Cancer Consortium, and founding editor of two research journals, one of which (Systems Biology and Medicine) won the American Publishers Awards for Professional & Scholarly Excellence (PROSE) top award for outstanding scholarly work in all disciplines of the arts and sciences. The Smithsonian Museum deposited in their permanent collection a copy of the MGI-MGD software as an example of Innovation in Information Technology. Among his recognitions are an National Institutes of Health Pioneer Award and election as Fellow of the American Association for the Advancement of Science.
Dr. Abdel B. HALIM
Biomarkers and Diagnostics Consulting, NJ, USA
The Role of Biomarkers in Precision Medicine: Opportunities and challenges
Dr. Abdel B. Halim, PharmD, PhD, DABCC, FAACC, is an internationally-recognized key opinion leader with 25+ years of experience in different aspects of biomarkers, precision medicine and IVD; from strategic planning to actualization. He is the president of Biomarkers and Diagnostics Consulting providing consultations and services to pharma, biotech, IVD and clinical labs. Abdel has served on 20+ governmental and public expert panels and advisory boards in the US, Canada and EU. Dr. Halim held multiple leadership positions in the pharmaceutical and diagnostic industries. He oversaw the development and validation of assays for several hundreds of biomarkers on different platforms and their applications in 200+ PI-PIV clinical trials and patient managements. He has led 7 CDx programs and has track records for 5 FDA 510K approvals of high complexity IVD and 2 drug approvals. Dr. Halim has served on 25+ committees to establish guidelines to promote quality in clinical laboratory and diagnostic industries. Abdel has 70+ peer-reviewed publications and 100+ presentations including 40+ invited and keynote speeches in national and international meetings.
Prof. Olli CARPEN
Helsinki University, Helsinki, FINLAND
Biobanking in Precision Medicine
Olli Carpén is professor of pathology at the University of Helsinki and scientific director at Helsinki biobank since 2015. He studied medicine at the University of Helsinki and continued his studies at Harvard Medical School. After returning to Finland, he specialized in pathology. From 2004 he served as a professor of pathology, and from 2013 as professor of biobank research at the University of Turku. He has been elementary in creating the Finnish biobank network and providing expertise within the international biobanking community. He is passionate in implementing biobanking into health care and personalised medicine research. His additional research interest is cancer, especially mechanisms of chemoresistance and discovery of prognostic and predictive biomarkers.
Prof. Nicolas VUILLEUMIER
Geneva University Hospital, Geneva, SWITZERALAND
Laboratory Medicine as a Key Driver in Precision Medicine
Nicolas Vuilleumier is a Professor at the Faculty of Medicine UNIGE and Head of the Laboratory Medicine Department at HUG. Nicolas Vuilleumier obtained a medical degree in 1999 at the University of Geneva. He then completed a specialization in internal medicine and a second in laboratory medicine. He also obtained a doctorate in medicine and a master’s degree in medical biology. After a two-year post-doctoral training at the Karolinska Institute (Sweden), from 2006 to 2008, he returned to Geneva where he continued his research on the role of humoral autoimmunity in atherogenesis, in parallel with his clinical activities in the Laboratory Medicine Department of HUG, and teaching. More recently, he is working on the unification of biobanks and biospécimens as part of specialized medicine. His work has been supported by the SNSF since 2011 and he is the winner of the Leenaards Prize in 2013. At the hospital level, he has held the position ad interim of Chief Medical Officer of the HUG Laboratory Medicine Department since 2013, before being appointed to this position in 2018. His a the acting president of the Swiss Society of Clinical Chemistry.
Prof. Jürgen BROCKMÖLLER
Göttingen University, Göttingen, GERMANY
The Role of Drug Monitoring in Precision Medicine
Jürgen Brockmöller was born in 1958 in Bonn, Germany. After his medical studies and approval as physician, he worked from 1993 to 1997 as PhD student at the Max-Planck-Institute of Molecular Genetics in Berlin on the structure of ribosomal proteins. From 1987 to 1993, Jürgen Brockmöller was postdoctoral fellow at the Institute of Clinical Pharmacology at the University Medical Center Benjamin Franklin in Berlin. He has the board certification in Clinical Pharmacology and his research focussed on pharmacogenetics and pharmacogenomics with emphasis on pharmacokinetics, drug transport and drug metabolism. From 1993 to 2000, Dr. Brockmöller was senior lecturer at the University Medical Center Charité in Berlin and since 2000, Dr. Brockmöller is director of the Institute of Clinical Pharmacology at the Georg August University Göttingen, Germany. Dr. Brockmöller is chairman of the Ethics committee at the Medical Faculty of the Georg-August-University Göttingen. From 2005 to 2015, Dr. Brockmöller was chairman of a postgraduate training and research initiative on pharmacogenetics in oncology supported by the German Research Foundation. He served as a scientific advisor and as a member of scientific advisory boards and safety committees for several pharmaceutical companies. The department of clinical pharmacology under the directorship of Dr. Brockmöller has the approval for postgraduate training in clinical pharmacology. Dr. Brockmöller has contributed to more than 260 peer reviewed scientific papers in the fields of molecular genetic epidemiology, pharmacoepidemiology, molecular and functional genetics, and molecular and clinical studies on genetically polymorphic drug membrane transport and drug metabolism. Present research priority of the Institute of Clinical Pharmacology of the University Medicine Göttingen is functional genomics with focus on drug membrane transport and drug biotransformation. Both, with scientific projects and our daily activities, we want to contribute to the clinical application of pharmacogenetic diagnostics in individualized medicine.
Dr. Abdellah TEBANI
Science for Life Laboratory, KTH, Stockholm, SWEDEN
Rouen University, Rouen, FRANCE
Data Sciences and Predictive Analytics in Precision Medicine
Abdellah TEBANI, PharmD, PhD, is trained as a Clinical Biochemist with a fellowship in Inborn Errors of Metabolism at Robert Debré Hospital (APHP) earning an Advanced degree in Medical Biology from Paris-Sud University, France. Meanwhile, he obtained a Master degree in Analytical Development Strategies and chemometrics from School of Pharmacy, Paris-Sud University and a PhD in Medical Sciences (Clinical omics) from Normandie University. As a Clinical Biochemist at the Department of Metabolic Biochemistry at Rouen University Hospital he developed and implemented high-throughput metabolomics strategies for the diagnosis of Inborn Errors of Metabolism using machine learning techniques and mass spectrometry along with other omics. As an instructor in Medical Biochemistry at Rouen School of Medicine, he’s also actively involved in education, outreach, and teaching. Thus, combining his medical background and data analytics passion, he’s focused on designing and delivering courses to undergraduate students and medical residents to introduce biochemistry, clinical chemistry, chemometrics, data analytics, experimental design, systems biology and omics-based tools in research and clinical settings. He is now a postdoctoral fellow at SciLifeLab in Stockholm (Sweden) working on integrative omics and multivariate data modelling. Abdellah TEBANI is passionate about innovations in artificial intelligence technologies, digital health and data sciences, and defines himself as a Precision Medicine enthusiast.
Prof. Philippe LAMBIN
Maastricht University, Maastricht, NETHERLANDS
Radiomics: Bridging Medical Imaging and Precision Medicine
Philippe Lambin is a Clinician, Radiation Oncologist, “ERC advanced & ERC PoC grant laureate”, co-inventor of Radiomics and Distributed learning and pioneer in translational research with a focus on tumour hypoxia and immunotherapy. He has a PhD in Molecular Radiation Biology and is Professor at the University of Maastricht (Radiation Oncology) He is co-author of more than 458 peer reviewed scientific papers (Hirsch Index: 85 Google scholar), co-inventor of more than 18 patents (filed or submitted) and (co) promoter of more than 50 completed PhD’s. He is currently involved in several successful European grants (e.g. Metoxia, Eureca, Artforce, Radiate, Quick-Concept, Requite, BD2decide, Predict) including ImmunoSABR (6 millions €, a multicentric randomized trial in metastatic lung cancer comparing radiotherapy plus or minus immunotherapy with immunocytokine). More recently, his interests have been directed towards hypoxia targeting, Hypoxia Activated Prodrugs, during immunotherapy. He is one of the inventor of “Distributed learning” a revolutionary Big Data approach for health care (watch the animation of a project he managed) and “Radiomics” (watch the animation).
Prof. Peter LAUSSEN
Toronto University, Toronto, CANADA
The Patient’s Journey in Intensive Care
Dr. Laussen was appointed as the Chief of the Department of Critical Care Medicine at The Hospital for Sick Children in Toronto in September 2012, and is the first incumbent of the David and Stacey Cynamon Chair in Critical Care Medicine. In addition to leading the Department of Critical Care, Dr. Laussen’s other leadership roles at SickKids include being Chair of the Medical Advisory Committee, member and past Chair of the hospital-wide Mortality & Morbidity Committee, and membership on the Clinical Operations Council and the Quality Management Council for the hospital. Dr. Laussen is a Senior Associate Scientist in the Research Institute, and Professor of Anaesthesia at the University of Toronto. After graduating from Melbourne University Medical School in 1980, he completed fellowships in anesthesia and pediatric critical care at the Austin and Royal Children’s Hospitals in Melbourne, and was appointed to the staff in the Department of Anesthesia at the Royal Children’s Hospital from 1989 to 1992. In 1992, he moved to Boston Children’s Hospital, where he joined the faculty on the cardiac anesthesia service, Department of Anesthesia, and in the Division of Cardiovascular Critical Care, Department of Cardiology. Between 1996 and 2002, he was the co-director of the cardiac anesthesia service, and was appointed the first incumbent of the DD Hansen Chair in Pediatric Anesthesia. Between 2002 and 2012, he was Chief of the Division of Cardiovascular Critical Care in the Department of Cardiology and appointed as Professor of Anaesthesia at Harvard Medical School in 2008. In addition to clinical and teaching responsibilities, Dr. Laussen led a large clinical research program in pediatric cardiac anesthesia and intensive care at Boston Children’s Hospital, focusing on the perioperative management of newborns, infants, children, and adults with critical congenital and acquired heart disease. Dr. Laussen has experience in aspects of systems and human engineering applied to critical care, and has published and lectured on wide-ranging quality assurance initiatives in paediatric critical care. He is the lead developer of an innovative web-based program which enables clinicians to track in real-time the trajectory of patients during treatment in the critical care unit, and in turn, trigger new responses in management (Tracking, Trajectory, Trigger tool, or T3). This innovative tool provides meaningful visualization and integration of bedside physiologic data for clinicians in the critical care unit, and will also act as a hosting platform for the collection, storage, sharing and analysis of large amounts of physiologic information to develop predictive treatment algorithms. Dr. Laussen is also a co-founder of the internationally renowned risk management symposiums Risky Business (risky-business.com) which brings together leaders in high-risk industries to discuss ways of improving the safety and quality of health care.
Prof. Stefan SCHULZ
Graz University, Graz, AUSTRIA
Clinical Informatics Challenges in Precision Medicine
Stefan Schulz is a full professor of Medical Informatics at the Medical University of Graz, Austria. Trained as a physician, his research encompasses electronic health records, medical language processing, biomedical terminologies, and the application of formal ontologies for biomedical knowledge representation. He has contributed to the development of clinical terminology standards such as WHO classifications and SNOMED CT. He is currently leading a project on semantic clinical data enhancement for biomarker research and improved usability for electronic patient records.
Prof. Ron WEVERS
Radboud University Medical Centre, Nijmegen, NETHERLANDS
The Panomics Revolution in Inherited Metabolic Diseases
Prof Ron Wevers holds a chair in Clinical Chemistry at the Radboud University Medical Centre in Nijmegen in the Netherlands. The focus of this chair is on clinical chemistry of inborn errors of metabolism and more specifically on neurometabolism. Until recently he was member of the Dutch Health Council (2003-2015), member of the Praesidium committee of the Dutch Health Council (2013-2015) and was board member of the Nijmegen Clinical Genetics Centre 2005-2017. Prof Wevers was trained as a clinical chemist in Utrecht and works in Nijmegen since 1981. In 2001 he obtained an additional professional registration as clinical biochemical geneticist. Currently Prof Wevers was head of the Translational Metabolic Laboratory (TML) in the department of Laboratory Medicine in Nijmegen. The TML laboratory is a fully accredited mixed function laboratory with patient care and translational research. The laboratory has approximately 140 fte including 15 staff members among whom six academic chairs. Per year there are 150-200 peer reviewed scientific papers from this laboratory. Around 480 scientific papers (co)authored by Prof Wevers appeared in peer reviewed journals (source: pubmed). The papers have been cited 18929 times. Prof Wevers gave 180 international lectures. His H-index amounts to 72 (source: Google scholar). Prof Wevers is retired since august 2017.
Prof. Jean-Louis GUEANT
Lorraine University, Nancy, FRANCE
A multi-omic approach reveals a new type of inherited errors of vitamin B12 metabolism
Jean-Louis Guéant, MD, DSc, is Professor of Medical Biochemistry-Molecular Biology at the University of Lorraine, Faculty of Medicine, Director of UMR-S Inserm 1256, Head of the Department of Biochemistry-Molecular Biology-Nutrition at the University Hospital of Nancy. He followed a MD, PhD double cursus at the Faculty of Medicine and the Faculty of Sciences of the University Henri Poincaré of Nancy, with the qualification in Hepato-Gastroenterology in 1984, and the degree of Doctor of Science in Nutrition in 1986. He is recruited as Master of Conferences – Hospitaller Practitioner in 1987 and appointed Professor of Universities – Hospital Practitioner in 1990. Prior to this appointment, he made several post doc stays at the State University of New York and the Institute Minerva of Helsinki (with R Gräsbeck as mentor). He then directs one of the 3 research teams of Inserm Unit 308 (director JP Nicolas) from 1988 and obtains the creation of an EP-CNRS team in 1996, which will become EMI-Inserm in 1999, then UMR-S Inserm 724 in 2002, UMR_S Inserm 954 in 2009 and UMR_S Inserm 1256. This Inserm Unit brings together nearly 70 people, including 3 Inserm researchers and 36 academic investigators in experimental and clinical research, around a research project on the interactions between nutrition, genes and the environment. In this context, he has been principal investigator of many national contracts. In hospital, he has contributed to the creation of the Reference Center for Rare Diseases of Metabolism in which he carries out a very specialized medical consultation on rare metabolic diseases with a regional, national and international recruitments of patients.
Prof. Mathias UHLEN
Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, SWEDEN
The Human Protein Atlas
Implications for human biology, drug development and precision medicine
Mathias Uhlen is professor at the Royal Institute of Technology (KTH), Stockholm, Sweden. His research is focused on protein science, antibody engineering and precision medicine and ranges from basic research in human and microbial biology to more applied research, including clinical applications in cancer, infectious diseases, cardiovascular diseases, autoimmune diseases and neurobiology. He leads an international effort to systematically map the human proteome to create a Human Protein Atlas (www.proteinatlas.org) using antibodies and various omics technologies. This effort has so far resulted in the Tissue Atlas (2015) showing the distribution of proteins across human tissues and organs, the Cell Atlas (2016) showing the subcellular location of human proteins in single cells and the Pathology Atlas (2017) showing how cancer patient survival is tied to RNA and protein levels.. He is the President of the European Federation of Biotechnology and from 2010-2015, he was the founding Director of the Science for Life Laboratory (SciLifeLab) which is a Swedish national center for molecular bioscience.